DNS stands for two different things:

Domain Name System – not exactly German, but the abbreviation is used all the same.  The Domain Name System is effectively the address book of the internet.  It is the system that converts addresses such as www.germanwordsexplained.com into their equivalent IP addresses, eg. 81.169.145.66

Desoxyribonukleinsäure – known in English as DNA.  The English abbreviation is now more commonly used in German, especially in texts that have been translated.  The older form can often be heard in films that were dubbed in the 1980s or at the beginning of the 1990s.

To hear a simple explanation and a short discussion in German, listen to the podcast:

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